Blogs

Boost Kidney Health with LPC Omega-3 DHA/EPA Supplements!

Kidney health is a growing concern around the world and issues are more common than you may think.

For example, Acute Kidney Injury (AKI) is a major global health issue, affecting around 13.3 million people yearly. Depending on the country’s economic status and the severity of AKI, death rates range from 20 per cent to 50 per cent. In wealthier nations, AKI mostly occurs in hospitals, especially in intensive care units, where it can affect up to 60 per cent of patients. Despite its prevalence, there are no specific treatments — only supportive care. AKI can also lead to chronic kidney disease, requiring dialysis.

One major cause of AKI is ischemic–reperfusion injury (IRI), which happens when blood supply returns to the kidney after a period of low oxygen. This triggers damage, including inflammation, oxidative stress and scarring, which can lead to long-term kidney problems. 

What’s more, Chronic kidney disease (CKD), which can lead to kidney failure, is estimated to affect more than 10 per cent of the population. When the kidneys are damaged — whether from surgery, infections, or other factors — their ability to heal depends on certain cells in the kidney. If these cells fail to recover properly, scarring (fibrosis) occurs, often requiring dialysis or a transplant.

There are measures being looked into to improve kidney health and new research has shown some exciting developments. 

Does Omega 3 Improve Kidney Function?

Omega-3 from seafood may help lower the risk of CKD and slow kidney decline. A study found that people with higher seafood omega-3 levels had an 8 per cent lower risk of CKD, with three specific omega-3s — EPA, DHA and DPA — linked to this benefit.

Another study examined data from nine clinical trials (444 participants) to determine the effects of omega-3 fatty acids on kidney health. The results suggest that omega-3 supplements may help reduce protein in the urine (proteinuria) and lower the risk of end-stage kidney disease (ESRD), but they did not significantly impact creatinine clearance (CCR) or estimated glomerular filtration rate (eGFR), which are common measures of kidney function.

Previous studies had mixed results on omega-3’s benefits for kidney disease, with some showing no clear effect and others suggesting a reduction in proteinuria. This study, however, found stronger evidence that omega-3s help with proteinuria, possibly by improving blood pressure control, a key factor in kidney disease progression.

This is the reason recent research into LPC omega-3 is so exciting, because studies have shown it may improve kidney repair.

Further Reading: The Difference Between LPC DHA and LPC EPA

LPC Omega 3 and Kidney Regeneration

As mentioned above, studies show that AKI disrupts the balance of lipids (fats) in kidney cell membranes, affecting their structure and function.

A key player in kidney lipid balance is a protein called Mfsd2a. This transporter helps move a type of fat called lysophosphatidylcholine (LPC), which is rich in omega-3 fatty acids like DHA, into cells. LPCs play a role in maintaining and repairing cell membranes. Previously, Mfsd2a was known for its role in brain development, but researchers have now found that it is also active in the kidney.

A study found that Mfsd2a is important for kidney recovery after IRI. In experiments with mice, those with reduced Mfsd2a levels struggled to recover from kidney injury, but supplementing them with LPC-DHA helped restore kidney function and repair damaged membranes. This suggests that boosting LPC-DHA levels could be a potential treatment for AKI.

Research has also linked Mfsd2a to diabetic kidney disease, suggesting that low Mfsd2a levels or a lack of LPC-DHA in the blood might contribute to kidney damage in other conditions. Since both AKI and diabetic kidney disease share common damage pathways, LPC-DHA supplementation could be beneficial in multiple kidney disorders.

These findings suggest that LPC-DHA supplementation could help protect kidney function after injuries like surgery or infections. It may also benefit kidney transplant patients by improving donor organ recovery. 

Further Reading: What is the Best EPA to DHA Ratio for Optimal Health?

Taking LPC Neuro for Kidney Repair

With this exciting research in mind, taking an LPC omega-3 supplement may be something to help repair kidney damage by restoring cell membrane function and reducing scarring.

Xandro’s LPC Neuro is a science-backed solution for your health, whether it be kidney, brain or eye health. Our LPC-DHA supplement is designed to support kidney health and recovery, making it a potential aid for individuals at risk of kidney disease, those recovering from surgery or even kidney transplant patients.

If you or a loved one are managing kidney or cognitive concerns, talk to your doctor about LPC Neuro. Whether you're preparing for a transplant, recovering from an illness or simply looking to support your long-term health, LPC Neuro is a cutting-edge solution backed by science.

Further Reading: Introducing LPC Neuro: A LYSOVETA® LPC-DHA/EPA Supplement for Brain Health

End Note

While more research on humans is needed, LPC omega-3 is a promising supplement that can help with a range of health issues. Be sure to check out the ‘further reading’ blogs listed throughout this one to learn more about how LPC omega-3 can improve your brain health and longevity.

On the lookout for LPC-DHA/LPC-EPA supplements? Try out Xandro’s LPC Neuro, advanced omega-3 for the brain.