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What Is New in Longevity Research in June 2024?

What’s the latest in human longevity news? In this month’s longevity newspaper, learn about longevity lifespan and how to increase longevity, including DNA longevity and potential longevity supplements based on the latest longevity research.

Once you’re finished, read our previous months’ longevity news 2024 to catch up on what you’ve missed in anti aging news!

Helping Improve Alzheimer’s Disease

A study has found that a lifestyle of a vegan diet, exercise, supplements and stress management can improve symptoms of Alzheimer’s.

It was found that these improved three of four measures of cognition and function, and two types of amyloid-B peptides, the concentration of harmful LDL cholesterol and microbiome composition.

Currently, there are around 12 modifiable factors that make up 40 per cent of the world’s dementia cases, but lifestyle factors haven’t yet been tested.

This study on 51 Alzheimer’s disease patients ran for 20 weeks and consisted on a minimally processed vegan diet high in complex carbs and low in harmful fats, sweeteners and refined carbohydrates.

Each individual completed aerobic physical activity for at least 30 minutes a day and mild strength training at least three times a week, as well as practiced meditation, yoga, stretching, relaxation and breathing exercises for one hour each day for stress management.

They also took omega-3, curcumin, a multivitamin, vitamins C and B12, coenzyme Q10, magnesium, probiotics and lion’s mane mushroom supplements.

Corylin for Osteoporosis

A study has found that corylin, a plant commonly used in Chinese medicine, may have benefits when used as an osteoporosis treatment.

It was previously researched for its effects on aging and its benefits on inflammation, oxidative stress and cancer, but a mouse study has found it may improve osteoclast production and bone loss, although not to control group levels.

The results require more comprehensive animal and human trials to determine whether Corylin may be used in future osteoporosis treatments.

NAD+ for Sarcopenia

A study has found that N-methyltransferase (NNMT), a compound related to NAD+ precursors,

Sarcopenia, the loss of muscle that is common in older people, is closely linked with metabolic dysfunction, in which NAD+ plays a large role, and NNMT, which affects the gene expression of both DNA and nicotinamide, was found to be a biomarker of sarcopenia.

In naturally aged mice, NNMT saw an improvement in age-related loss of lean mass, grip strength, metabolism and muscle mass.

The results are encouraging and suggest sarcopenia may be controlled or protected through this small molecule or gene therapy.

Oral Health and Alzheimer’s Disease

A link has been found between oral microbial diversity and executive function performance.

While the study did not give a clear answer, showed a link between microbiome diversity and executive function, processing speed and subjective memory changes.

The study suggests that changes to the microbiome in the mouth can be a potential source of low-grade systemic inflammation, which may play a role in the development of dementia and cognitive impairment.

Other indicators of dementia include a lower educational level, physical inactivity, systemic inflammation, such as diabetes, stroke and cardiovascular disease and toxin exposure.

Further Reading: Intermittent Fasting and Longevity

Whale DNA Helping With Human Longevity

Bowhead whales in the Arctic have a mechanism that protects their DNA from cancer, which may lead to ways of achieving longevity in humans.

Both previously studied elephants and bowheads have a large number of cells compared to humans yet do not see an increase in the incidence of cancer.

The whales can live for over two hundred years and scientists have found that they have a previously unknown process that repairs their damaged DNA in a way that slows down their aging.

These whales also have high levels of the proteins CIRBP and RPA2, which are known to increase the efficiency of DNA repair in humans, which is most likely an evolutionary result due to them living in ultracold temperatures and other physiological stresses.

The study is still to be peer-reviewed so results will be released in the coming future.

An Injectable NAD+ Booster

ChromaDex has introduced an injectable NAD+ booster through its Niagen+ IV treatment.

The company claims it can raise NAD+ levels faster and higher than previous IV therapies through its patented nicotinamide riboside (NR) NAD+ precursor form, and due to its commercialisation, it’s now one of the most well studied NAD+ precursors on the market.

The product will be available in limited quantities in IV, shot and push forms at select clinics with a prescription starting in August.

Further Reading: How Do We Define Longevity?

Extending Maternal Care Leads to Long, Slow Lives

A study has found that in species that have a long-term presence of a mother, they tend to have longer lives of a slower pace.

These links include having longer lives and reproducing less often and can be associated with mammals overall.

The work also builds upon the Mother and Grandmother hypothesis that suggests menopause may also occur so that older females can focus on caring for grandchildren.

The results suggest that the behavioural link between mother and child, while weakening over time, never fully goes away and may link to human longevity.

A New Deficiency That May Contribute to Aging

C15:0 deficiency may lead to accelerated aging in younger people, a new study has found.

As the first nutritional deficiency syndrome discovered in over 75 years, C15:0, or Cellular Fragility Syndrome, has been linked to various nutritional deficiencies

This syndrome is caused by low levels of pentadecanoic acid (C15:0), which is found in whole dairy products, certain fish and some plants, and may impact 1 in 3 people worldwide.

Those with low C15:0 levels are at a higher risk of developing type 2 diabetes, heart disease and non-alcoholic fatty liver disease, with C15:0 needed for cellular integrity.

A C15:0 deficiency is associated with cells becoming fragile, possibly contributing to ferroptosis, a form of cell death, that has been suggested to accelerate aging and the development of chronic diseases.

Changes in agricultural practices and the decline in the consumption of whole-fat dairy products have led to a population decline in C15:0 levels, with the study suggesting C15:0 supplementation can stabilise cell membranes, repair mitochondrial damage and reduce oxidative stress, helping individuals improve their healthspan.

End Note

Enjoyed this issue of human longevity latest news and are interested in learning about more longevity research news? Check out our previous months’ newsletters full of longevity research news, exercise for longevity, average longevity and various longevity clinics and longevity companies. Head there here: January, February, March, April and May.