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Comparison of Longevity Blend Supplements: Ingredients & Reviews

With so many longevity blends on the market, it’s hard to know which ones actually work and which are just hype. 

For that reason, we’ve analysed a range of longevity blends and compared them to help you in your decision for which one is best for you. 

We’ll break down our longevity products reviews by the ingredients, pricing, scientific backing and real-world benefits to help you decide: what is the best longevity supplement?

Jump there now:

• Xandro’s Protocol X
• AgeMate’s Daily Longevity Blend
• Bryan Johnson’s Blueprint
• DecodeAge’s LongeVit
• YouthandEarth’s V14
• Novos’ Novos Core
• David Beckham’s IM8
• AG1
• Final Verdict: Which Longevity Blend is Best?

Xandro’s Protocol X – The All-Rounder

Price: USD$131 for 30 sachets
Where to Buy: Xandro Lab
Origin: Singapore
How to Take: Mix one sachet with 200–250ml of water or your preferred beverage, once per day, best taken on empty stomach.
Best For: People who want broad health support (not just anti-ageing)
Who Should Avoid: Generally safe but speak to your doctor beforehand if you’re pregnant. 

Key Features:

• 20+ longevity ingredients (NMN, Taurine, TMG, Ergothioneine)
• Targets 11 body functions (brain, heart, skin, metabolism, anti-ageing)
• Citrus-flavoured powder, easy to mix
• Travel-friendly sachets

Ingredients:

• Quercetin Dihydrate – 200mg
• Sialic Acid – 25mg
• Phosphotidylcholine – 100mg
• Pepwell™ GS 70 Collagen – 200mg
• Grapeseed Extract – 250mg
• CaAKG – 500mg
• Taurine – 1000mg
• Ergothioneine – 3mg
• Vitamin C – 200mg
• Vitamin D3 – 0.5mg
• CoQ10 – 30mg
• TMG – 200mg
• Spermidine – 1mg
• Fisetin – 50mg
• Creatine – 1000mg
• Ellagirush™ Pomegranate Extract – 250mg
• Serocen™ Centella – 100mg
• Sodium Hyaluronate – 50mg
• L-Glutamine – 800mg
• Liposomal NMN – 250mg

Does it work?

Protocol X includes well-researched anti-ageing compounds, but some doses (like NMN) are lower than competitors. Ca-AKG has been shown to extend lifespan in animal studies, while taurine is linked to longer lifespan in mice. Also contains fisetin, a senolytic, for deep anti-ageing. Good for general wellness, but not the strongest NAD+ booster.

Pros:

• Contains a bit of everything good for health (brain, heart, skin)
• Easy to take (just mix with water)
• Includes proven ingredients like Taurine and Vitamin D

Cons:

• NMN dose is lower than competitors
• A bit pricey compared to competitors

Verdict: Worth it if you want a broad-spectrum longevity supplement to cover all your bases.

Further Reading: The Science Behind Protocol X

AgeMate’s Daily Longevity Blend – Best for NMN

Price: USD$69 for 30 servings
Where to Buy: AgeMate
Origin: Australia (lab-tested in the USA)
How to Take:How many scoops of AgeMate per day? Just one scoop (3g) mixed with water. Start with half if sensitive.
Best For:Over 30s, those with fatigue, biohackers
Who Should Avoid:Those on blood thinners

Key Features:

• Does AgeMate have NMN? Daily Longevity Blend has 500mg per scoop, one of the highest doses available, which has been shown to be clinically effective.
• Glycine & Pterostilbene for anti-ageing synergy
• 17 other ingredients (Pterostilbene, Spermidine, Hyaluronic Acid)

AgeMate Longevity Blend Ingredients:

• NMN – 500mg
• Pterostilbene – 50mg
• Glycine – 700mg
• Hyaluronic Acid (as Sodium Hyaluronate) – 100mg
• L-Theanine – 100mg
• Magnesium (as Magneisum Malate) – 45mg
• Malate (as Magnesium Malate) – 255mg
• Methysulfonylmethane – 300mg
• Spermidine – 5mg
• Vitamin C (as Ascorbic Acid) – 250mg
• Vitamin D2 (1,000) IU – 25mcg
• Vitamin K2 MK-7 – 200mcg
• Vitamin B1 (as Thiamine HCI) – 25mg
• Vitamin B6 (as Pyridoxine HCI) – 10mg
• Vitamin B12 (as Methylcobalamin) – 50mcg
• Folate (as 5-MTHF) – 300mcg
• Choline (as Choline Bitartrate) – 50mg
• Sodium – 20mg

AgeMate Reviews: People report better energy and focus thanks to NMN. Some find the taste mild.

Pros:

• Strong 500mg NMN dose (one of the highest)
• Includes Pterostilbene
• Good price for the quality
• Independently tested for purity

Cons:

• Doesn't have Ca-AKG (another important anti-ageing ingredient)
• Some might find the taste bland
• In some rare cases, AgeMate side effects may include headaches, dizziness and an upset stomach in people due to the NMN.

Verdict: Best for NAD+ support if NMN is your priority, and energy. It contains key ingredients like spermidine to trigger autophagy and has a high dosage of NMN for a blend. NMN + Pterostilbene is a proven combo for energy & cellular repair, but it’s missing Ca-AKG & Fisetin, so not a full anti-ageing stack.

Further Reading: Why You Should Be Taking NMN For Longevity

Bryan Johnson’s Blueprint Longevity Mix – High-Dose Formula

Price: USD$49 for 30 servings
Where to Buy: Blueprint
Origin: USA (developed by Bryan Johnson’s team)
How to Take: Mix one level scoop with 6–24 ounces of water in your cup, with food.
Best For: Athletes, gym-goers
Who Should Avoid: Those with kidney issues

What is Bryan Johnson’s Blueprint?

A high-potency mix with 13 actives, including:

• 2000mg Ca-AKG (longevity benefits)
• 2500mg Creatine (muscle & brain)
• 1500mg Taurine (heart & metabolism)

What’s in Bryan Johnson’s Longevity Mix? Mostly Creatine, Ca-AKG (for cell health), Taurine (for heart and metabolism), vitamin D3 (for immunity and bones), vegan collagen (for skin repair) — great for fitness, but not the best pure anti-ageing option.

• Carbohydrates – 3g
• Vitamin C (as Ascorbic Acid) – 250mg
• Calcium (from CaAKG) – 400mg
• Magnesium (as Magnesium Citrate) – 150mg
• Creatine (as Monohydrate) – 2500mg
• CaAKG – 2000mg
• Taurine – 1500mg
• Glycine – 1200mg
• L-Lysine (as HCI) – 1000mg
• Glycosamine Sulfate (as KCI) – 750mg
• L-Glutathione Reduced – 250mg
• L-Theanine – 200mg
• Sodium Hyalyronate – 120mg 

Does it work? Yes, but expensive. The creatine dose is high (good for gym-goers), but some ingredients lack research for longevity.

Pros:

• Very high dose of Creatine (great for gym-goers)
• Contains Ca-AKG (good for longevity)
• Bryan Johnson supplements are developed by a famous biohacker

Cons:

• Expensive for what it is
• Missing NMN and other key anti-ageing ingredients
• More focused on fitness than pure longevity

Verdict: Good for muscle, performance and energy but overpriced for a pure anti-ageing supplement as it’s missing some key anti-ageing ingredients like fisetin and NMN. 

Further Reading: Bryan Johnson’s Supplement Stack

DecodeAge’s LongeVit – Best for NAD+ & Anti-Ageing

Price: USD~$35 for 30 tablets
Where to Buy: DecodeAge
Origin: India (popular in Asia, EU & USA)
How to Take: Take one tablet after breakfast or lunch
Best For: Those new to longevity supplements
Who Should Avoid: Don’t take if you’re pregnant, breastfeeding, are on medications or have underlying health conditions. 

Decode Age LongeVit Ingredients:

• β-Nicotinamide Mononucleotide (Decode Age® NMN) – 200mg
• CoQ10 – 100mg
• Pterostilbene – 50mg
• Curcumin – 75mg
• Piperine – 25mg
• L-Glycine – 100mg
• Hyaluronic Acid – 100mg
• Ginger Extract – 100mg
• Ginseng – 100mg
• Ca-AKG (Calcium Alpha-Keto Glutarate) – 80mg

Benefits:

• Boosts NAD+
• Supports brain & heart health
• Affordable

Decode Age review consensus: Good starter NAD+ booster

Pros:

• Most affordable option
• Contains NMN and CoQ10 (good for energy)
• Easy tablets (no mixing)

Cons:

• Lower NMN dose than others
• Missing some important ingredients
• Not as comprehensive as others

Verdict: Best budget NAD+ booster with solid science.

Further Reading: The Benefits of Calcium AKG for Athletes

Youth&Earth’s V14 – Most Comprehensive

Price: USD~$130 for 28 sachets
Where to Buy: YouthandEarth
Origin: UK
How to Take: Take one sachet in the morning, each day
Best For: Those who want NAD+ + antioxidants in one
Who Should Avoid: Generally safe but speak with your doctor if you are pregnant, breastfeeding, taking medication or have a medical condition.

Key Features:

• 14 longevity ingredients (NMN, Spermidine, Fisetin, Ca-AKG) 
• Superfruit antioxidants (Açaí, Pomegranate, Beetroot)
• 500mg NMN + 35mg Fisetin
• Great taste (berry flavour), easy to drink

V14 Longevity Reds Ingredients:

• Glycine – 2000mg
• Magnesium Malate – 2000mg (as Magnesium 300mg)
• Calcium Alpha-Ketoglutarate – 1000mg (as Calcium 200mg)
• NMN – 500mg
• Taurine – 375mg
• Vitamin C – 100mg
• Ginger (standardised to 2 per cent gingerols) – 80mg
• Fisetin – 35mg
• Pterostilbene – 35mg
• Quercetin Dihydrate – 35mg
• Trans Resveratrol (from Polygonum Cuspidatum Root) – 35mg
• Lutein – 10mg
• Astaxanthin – 4mg
• Zeaxanthin – 4mg
• Spermidine – 2mg
• Lithium – 1mg
• Vitamin K2 – 50mcg
• Vitamin D3 – 25mcg (1000 IU)
• Selenium – 200mcg

Youth and Earth Supplements – Worth it?

500mg NMN isa great dose for a supplement blend, with 45mg of fisetin to kill ‘zombie’ cells. The Ca-AKG also has lifespan benefits, so, overall, it’s one of the most complete blends. The superfood antioxidants also add extra benefits.

Pros:

• Great combo of NMN + Fisetin (zombie cell killer)
• Includes superfood antioxidants
• Tastes nice (berry flavour)

Cons:

• Expensive 
• Some ingredients are underdosed
• Comes in large sachets (less convenient)

Verdict: Best for antioxidant + NAD+ combo, but pricey.

Further Reading: Do Antioxidants Actually Extend Lifespan?

Novos Core – Most Scientifically Backed

Price: USD$109 for 30 servings
Where to Buy: Novos Labs
Origin: USA (developed by Harvard/MIT scientists)
How to Take: Add one sachet of NOVOS Core powder to your preferred cold or lukewarm beverage, with or after a meal.
Best For: Serious longevity enthusiasts, those willing to invest
Who Should Avoid: People with sensitive stomachs

Novos Core Ingredients:

• Glycine – 2000mg
• Pterostilbene – 50mg
• Fisetin – 100mg
• Malate – 1700mg (304mg magnesium)
• Magnesium – 304mg
• Glucosamine Sulfate – 1000mg
• L-Theanine – 159mg
• Rhodiola Rosea – 300mg
• Hyaluronic Acid – 100mg
• Vitamin C – 100mg
• Ginger – 100mg
• Microdosed Lithium – 20mg 

Novos Core Reviews:

• 81 per cent users feel benefits in 2 weeks
• Targets 12 ageing pathways
• Backed by Harvard/MIT scientists

Novos Core side effects? Rare, but high Fisetin may cause mild digestive upset.

Pros:

• Best science-backed formula
• Proper doses of Fisetin and Ca-AKG
• Developed by Harvard/MIT scientists

Cons:

• Expensive
• Might upset sensitive stomachs
• Only available on their website

Verdict: Best for anti-ageing science, but expensive. It’s the most science-backed blend with it’s own scientific studies conducted on mice (which experienced an 18 per cent life extension) that targets ageing pathways. Has a good amount of fisetin, Ca-AKG and glycine, too.

Further Reading: Ageing 101: The Hallmarks of Ageing

IM8 (David Beckham) – Best for Cellular Health

Price: USD$99 for 30 capsules
Where to Buy: IM8 Health
Origin: UK/USA
How and When to Take IM8: Take one capsule each morning, preferably with food
Best For: Those who hate powders
Who Should Avoid: People who are sensitive to stimulants

IM8 Ingredients:

• Niacin (as Cuprous Niacin) – 0.8mg
• Vitamin B12 (as Methylcobalamin) – 40mcg
• Folate (as Quatrefolic (6S)-5-Methyltetrahydrofolic acid glucosamine salt) – 400mcg DFE
• Selenium (as Selenium Amino Acid Chelate) – 100mcg
• Copper (as Cuprous Niacin) – 0.18mg
• NAD3 Complex (Proprietary blend of wasabi extract, theacrine, cuprous niacin) – 312mg
• DHA – 200mg
• Cell Rejuvenation Technology 8 – 25mg

Does IM8 have Vitamin D? No, but it has B12 & folate for energy.

IM8 vs AG1?

• IM8 = NAD+ & cellular health
• AG1 = Greens & digestion

Pros:

• Easy capsules (no mixing)
• Contains NAD+ boosters
• Famous brand backing

Cons:

• Missing key longevity ingredients
• Quite expensive for what’s in it
• Effects might be subtle compared to competitors

Verdict: Good for NAD+ in capsule form, but AG1 is better for vitamins. It’s not a longevity blend as it’s missing key longevity ingredients, rather, it’s a convenient multivitamin and food extract in capsule form. While the DHA, one of the omega-3s, is great to see, LPC-DHA is the form that best crosses the blood-brain barrier to improve brain and eye health.

Further Reading: What Form of Omega 3 Is Best?

AG1 – Best for Overall Nutrition

Price: USD$99 for 30 servings
Where to Buy: AG1
Origin: USA
How to Take: Mix one scoop with 8–10 ounces of cold water and drink it, preferably on an empty stomach.
Best For: Daily greens replacement
Who Should Avoid:

AG1 Benefits:

• 75 vitamins & minerals
• Digestive enzymes & probiotics, great for digestion
• Energy & immune support

AG1 Ingredients:

• Vitamin A (as beta-carotene) – 555mcg RAE
• Vitamin C (ascorbic acid) – 420mg
• Vitamin E (as D-alpha tocopherol succinate) – 83mg
• Thiamin (Vitamin B1) (as thiamine hvdrochloride) – 3mg
• Riboflavin (Vitamin B2) – 2mg
• Niacin (as nicotinic acid, nicotinamide) – 20mg NE
• Vitamin B6 (as pyridoxine hydrochloride) – 3mg
• Folate (as 5-MTHF) – 650mca DFE
• Vitamin B12 (as methylcobalamin) – 22mcg
• Biotin (Vitamin B7) – 330mcg
• Pantothenic acid (as calcium pantothenate) – 4mg
• Calcium (as calcium citrate 300mg, calciumcarbonate, calcium phosphate) – 118mg
• Phosphorus (as potassium phosphate 280mg, calcium phosphate) – 130mgMagnesium (as magnesium glycinate 200mg) – 26mg
• Zinc (as zinc citrate) – 15mg
• Selenium (as selenomethionine 5mg) – 20mcg
• Copper (as copper gluconate 2mg) – 195mcg
• Manganese (as manganese amino acid chelate 4mg) – 400mcg
• Chromium (as chromium picolinate) – 25mcg
• Sodium – 45mg
• Potassium – 300mg

Is AG1 actually worth it?

• Great for gut health
• If you want a super greens replacement 
• Not a pure longevity supplement as it lacks anti-ageing ingredients such as NMN and Ca-AKG)

Pros:

• Great for general health
• Packed with vitamins and greens
• Good for digestion

Cons:

• Doesn't contain anti-ageing ingredients
• Very expensive for a greens powder
• Doesn't help with longevity specifically

Verdict: AG1 Greens is one of the best daily greens powder/multivitamin but not focused on anti-ageing. It’s not a longevity supplement as it doesn’t contain longevity ingredients such as NMN, Ca-AKG or fisetin.

Further Reading: AG1 Review

Final Verdict: Which Longevity Blend is Best?

Top Picks:

• Best Budget: AgeMate (best NMN value)
• Best Science: Novos Core (most research-backed)
• Best All-Rounder: Protocol X
• Best Greens: AG1 (but not for anti-ageing)

If you avoid GMOs or gluten, all options here are safe. For halal, check with manufacturers directly.

Do longevity supplements really work?

Yes, but only if they contain proven ingredients like NMN, Ca-AKG, Fisetin and Pterostilbene. Avoid blends with fillers or weak doses, as many brands underdose key ingredients. Also, remember that greens powders won’t slow ageing, they’re for general health.

End Note

Which one will you try?

Remember, no single supplement does everything perfectly. The best one depends on what exactly you're looking for in your health routine and that suits your personal longevity program.

For us, we love AgeMate for NMN, Novos Core for deep anti-ageing and Protocol X for general healthy ageing.

You can get your hands on Protocol X, a longevity all-rounder multivitamin here!