Blogs

List of POM-Q10 research papers

This page includes a comprehensive list of research papers, clinical trials and more that detail the benefits of supplementation with POM-Q10 ingredients discovered to date. For easier reading and understanding, findings have been summarized in greater detail for you.

No.	Product	Date	Focus	Study Title	Link
01	Pomegranate	23/11/2016	Heart health	Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials	View Paper
02	Pomegranate	14/11/2022	Reduce signs of skin aging	Prospective Randomized Double-Blind Placebo-Controlled Study of Oral Pomegranate Extract on Skin Wrinkles, Biophysical Features, and the Gut-Skin Axis	View Paper
03	Pomegranate	28/03/2019	Exercise Performance	Pomegranate Extract Improves Maximal Performance of Trained Cyclists after an Exhausting Endurance Trial: A Randomised Controlled Trial	View Paper
04	Pomegranate	–/08/2015	Gut health	Pomegranate ellagitannins stimulate growth of gut bacteria in vitro: Implications for prebiotic and metabolic effects	View Paper
05	Amla	18/04/2011	Diabetes & Metabolic health	Effect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients	View Paper
06	Amla	27/11/2019	Vascular benefits	Clinical evaluation of Emblica Officinalis Gatertn (Amla) in healthy human subjects: Health benefits and safety results from a randomized, double-blind, crossover placebo-controlled study	View Paper
07	Amla	–/–/2009	Reduce oxidative stress	Supplementation of Emblica officinalis (Amla) extract reduces oxidative stress in uremic patients	View Paper
08	Coenzyme Q10	22/08/2016	Reduce signs of skin aging	The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study	View Paper
09	Coenzyme Q10	–/–/1997	Physical Performance	The effect of coenzyme Q10 on the exercise performance of cross-country skiers	View Paper
10	Coenzyme Q10	27/04/2020	Heart Health	Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement	View Paper

Above is a comprehensive list of research & clinical trials conducted to date.

Details of each study, including focus, study subjects, dosage, date & results or findings

Paper #01 - Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials

Summary: This paper presents a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating the effects of pomegranate juice consumption on blood pressure.

Publication Date: 23 November 2016

Focus: Potential cardioprotective benefits of pomegranate juice consumption, particularly its effects on blood pressure

Study Subjects: Meta-analysis of various RCTs; does not provide specific details about the study population

Dosage: The study considers different durations and doses of pomegranate juice consumption, categorizing them as >12 weeks or <12 weeks and >240cc or <240cc of pomegranate juice per day

Results/Findings: Consuming pomegranate juice significantly lowers both systolic and diastolic blood pressure, with an average reduction of 4.96 mmHg for systolic and 2.01 mmHg for diastolic. These positive effects are consistent, irrespective of the duration or daily amount consumed, making pomegranate juice a potential addition to a heart-healthy diet for blood pressure management.

Paper #02 - Prospective Randomized Double-Blind Placebo-Controlled Study of Oral Pomegranate Extract on Skin Wrinkles, Biophysical Features, and the Gut-Skin Axis

Summary: This study examines the effects of oral pomegranate extract from Punica granatum on various aspects of skin health, including wrinkles, biophysical properties, and the connection between the gut and skin.

Publication Date: 14 November 2022

Focus: Skin health and its influence on wrinkle severity, skin microbiome, and gut-skin interactions

Study Subjects: 28 healthy males and females aged 25-55 years

Dosage: 250mg of Pomella® pomegranate fruit extract standardized to 75 mg of punicalagins daily for four weeks

Results/Findings: The study revealed that taking oral pomegranate extract reduced wrinkles and improved skin properties. Participants experienced some decrease in excess oil, along with beneficial changes in skin and gut microbiomes. Overall, oral pomegranate extract had a positive impact on skin health.

Paper #03 - Pomegranate Extract Improves Maximal Performance of Trained Cyclists after an Exhausting Endurance Trial: A Randomised Controlled Trial

Summary: This study investigates the impact of pomegranate extract (PE) on the performance and post-exercise recovery of trained cyclists, particularly focusing on endurance and maximal effort.

Publication Date: 28 March 2019

Focus: Whether pomegranate extract can enhance the performance and recovery of male amateur cyclists following an endurance exercise trial

Study Subjects: 26 Male amateur cyclists with a training routine of 2 to 4 sessions per week (at least one hour per session)

Dosage: Oral supplement Pomella® containing 75 mg of punicalagin per capsule and the control group (n = 14) received an oral placebo for daily consumption for four weeks.

Results/Findings: Pomegranate extract significantly improved the total time to exhaustion and the time to reach ventilatory threshold 2, indicating enhanced performance in maximal effort exercises. However, it did not have a significant impact on force restoration in damaged muscles. In summary, pomegranate extract appears to be effective in improving maximal exercise performance and may aid in post-exercise recovery.

Paper #04 - Pomegranate ellagitannins stimulate growth of gut bacteria in vitro: Implications for prebiotic and metabolic effects

Summary: This study examines the effects of pomegranate extract (POMx) and pomegranate juice (POM juice) on the growth of specific groups of intestinal bacteria and their potential use as prebiotics.

Publication Date: – August 2015

Focus: Impact of pomegranate extract and juice on the growth of various intestinal bacteria groups and the utilization of pomegranate polyphenols by beneficial bacteria.

Study Subjects: Stool specimens and select bacteria strains used in in vitro experiments

Dosage: POMx and POM juice at different concentrations were incubated with stool specimens and bacterial strains (400, 100, and 25 μg/ml)

Results/Findings: Pomegranate extract and juice increased the growth of beneficial Bifidobacterium and Lactobacillus, while inhibiting the growth of less favorable bacteria groups. The study suggests that pomegranate may potentially act as a prebiotic, promoting the growth of beneficial gut bacteria, and highlights the potential role of polyphenols in influencing gut microbiota and human health.

Paper #05 - Effect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients

Summary: This study assesses the impact of Emblica officinalis Gaertn. fruit on blood glucose and lipid levels in both normal subjects and individuals with type 2 diabetes.

Publication Date: 18 April 2011

Focus: Anti-hyperglycemic and lipid-lowering properties of Amla Fruit

Study Subjects: Normal and type 2 diabetic volunteers

Dosage: Participants received 1, 2, or 3 grams of E. officinalis powder per day

Results/Findings: The study found that daily consumption of Emblica officinalis fruit powder significantly reduced blood glucose levels and improved cholesterol & lipid profiles in both normal and type 2 diabetic subjects after 21 days of intake. These effects suggest potential benefits for glycemic control and cardiovascular health.

Paper #06 - Clinical evaluation of Emblica Officinalis Gatertn (Amla) in healthy human subjects: Health benefits and safety results from a randomized, double-blind, crossover placebo-controlled study

Summary: This study assesses the health benefits and safety of Emblica Officinalis Gatertn (Amla) supplementation in healthy adults.

Publication Date: 27 Nov 2019

Focus: Effects of Amla supplementation on vascular function, blood biomarkers, and various health parameters in healthy adult subjects

Study Subjects: 15 healthy adult subjects

Dosage: Subjects received either Amla (500 mg per day) or a placebo for 18 weeks

Results/Findings: Amla intake resulted in improved blood fluidity and showed positive effects on multiple health markers. These included reduced oxidative stress (measured by 8-OHdG and thrombin biomarkers), increased HDL-cholesterol, and lowered LDL-cholesterol levels. The study found no adverse events, safety concerns, or tolerance issues associated with Amla consumption

Paper #07 - Supplementation of Emblica officinalis (Amla) extract reduces oxidative stress in uremic patients

Summary: This study examines the impact of Amla extract supplementation on oxidative stress in patients with uremia.

Publication Date: – – 2009

Focus: Whether Amla extract, known for its antioxidant properties, can reduce oxidative stress in uremic patients

Study Subjects: Patients with uremia

Dosage: Amla extract supplementation over 4 months

Results/Findings: Amla extract supplementation significantly reduced oxidative markers (8-iso-prostaglandin) and increased total antioxidant status (TAS) in uremic patients.

Paper #08 - The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study

Summary: This study explores the impact of daily Coenzyme Q10 (CoQ10) supplementation on skin parameters and condition.

Publication Date: 22 August 2016

Focus: Effects of 12 weeks of daily CoQ10 supplementation on skin health

Study Subjects: 33 healthy subjects

Dosage: Daily supplementation with 50 and 150 mg of CoQ10 for 12 weeks

Results/Findings: CoQ10 supplementation limited seasonal deterioration of skin viscoelasticity and reduced visible signs of skin aging, including wrinkles, microrelief lines, and improved skin smoothness.

Paper #09 - The effect of coenzyme Q10 on the exercise performance of cross-country skiers

Summary: This study investigates the effects of Coenzyme Q10 supplementation on the physical performance of Finnish top-level cross-country skiers.

Publication Date: – – 1997

Focus: Impact of CoQ10 on physical performance in athletes

Study Subjects: 25 Finnish top-level cross-country skiers

Dosage: Coenzyme Q10 supplementation at a daily dose of 90 mg

Results/Findings: CoQ10 supplements improved athletes' physical performance, including their endurance (AET), anaerobic capacity (ANT), and maximum oxygen consumption (VO2Max). Additionally, 94% of athletes felt that CoQ10 helped them perform better and recover faster, compared to only 33% when they took a placebo. This suggests that CoQ10 may be beneficial for athletic performance and recovery.

Paper #10 - Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement

Summary: This paper reviews the effects of Coenzyme Q10 (CoQ10) supplementation on heart failure (HF) patients and its potential benefits.

Publication Date: 27 April 2020

Focus: Investigating the effects of CoQ10 supplementation on Heart Failure patients

Study Subjects: Patients with heart failure

Dosage: Varied across different studies

Results/Findings: For patients with heart failure (HF), lower CoQ10 levels are linked to more severe symptoms like fatigue, reduced exercise capacity, and difficulty breathing. In a study of HF patients, those with higher CoQ10 levels had milder symptoms (NYHA class I and II), while patients with worse symptoms (NYHA class III and IV) had lower CoQ10 levels. Taking CoQ10 supplements effectively restored CoQ10 levels in both the heart muscle and blood.