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Best Longevity Supplement Stack: Stacking Protocol with other Longevity Supplements

Want to boost your longevity game? Protocol X is a powerful new supplement designed to support healthy ageing but pairing it with the right stack can take your results to the next level.

Where does Protocol X fit in your supplement stack?

When building your longevity supplement stack, remember that not all supplements play nice together. Some compete for absorption, while others work best when taken at specific times. 

To help you make the most of your routine, we’ve put together a simple guide on how to safely and effectively stack Protocol X with other top longevity supplements.

Further Reading: What is Protocol X?

Key Protocol X Ingredients

Before mixing supplements, it’s important to know what’s in Protocol X. It contains 

• NAD+ boosters (like NMN or NR): Supports cellular energy and repair.
• Resveratrol: Activates longevity pathways (often taken with fat for better absorption).
• Senolytics: Help clear out aging ‘zombie’ cells.
• Antioxidants: Fight oxidative stress.

Specifically, here’s what’s in Protocol X:

• CaAKG – 500mg
• Citrusvel® Citrus Bioflavonoids Complex – 100mg
• CoQ10 – 30mg
• Creatine – 1000mg
• Ergothioneine – 3mg
• NMN – 250mg
• Phosphotidylcholine – 100mg
• Quercetin – 100mg
• Sialic Acid – 25mg
• Sodium Hyaluronate – 50mg
• Spermidine 3HCL – 1mg
• Taurine – 1000mg
• TMG – 200mg
• Vegan Collagen Booster VC-H1® – 2000mg
• Vitamin C – 400mg
• Vitamin D3 – 25mcg
• Whole Food Complex – 1000mg

Further Reading: Learn all about the science behind Protocol X ingredients

Now, let’s see how to combine Protocol X with other popular anti-ageing supplements.

Best Supplements to Stack with Protocol X

Protocol X already covers NAD+ support (NMN, TMG), antioxidants, collagen and cellular health boosters, but you can boost its effects with these safe, synergistic supplements:

1. Resveratrol: Resveratrol pairs well with quercetin (in Protocol X) for better anti-inflammatory effects. Take it with a meal containing healthy fats (olive oil, avocado) for best absorption.
2. Omega-3s (Fish Oil): When taken in their LPC-bound form, like LPC Neuro, omega-3s support brain health, reduce inflammation and keep your heart strong. They pair great with Protocol X’s phosphatidylcholine for brain health. 
3. Fisetin: A stronger version of quercetin (which is already in Protocol X). Take it once a month to help clear out old, worn-out cells
4. Probiotics: Keep your gut happy so you absorb all the good stuff in Protocol X better. A healthy gut means better results.
5. Zinc: Helps your immune system (not in Protocol X). Good for fighting off colds and keeping inflammation low.
6. Magnesium (Glycinate or Threonate): Relaxes your muscles and mind for deeper sleep. Works great with taurine (already in Protocol X).
7. Apigenin (from chamomile tea or supplements): Calms your brain at night, like a natural sleep aid without grogginess.
8. Protein Powder (Whey or Pea Protein): Helps build muscle, especially if you work out. Combines well with the creatine in Protocol X.

Supplements to Avoid Mixing with Protocol X

Some supplements clash, either by blocking absorption or causing side effects. Here’s what to watch out for:

• High-Dose Antioxidants (like mega Vitamin C or NAC): Can sometimes block the benefits of exercise and longevity supplements.
• High-dose Calcium and Iron: Can block each other’s absorption, so take them at least two hours apart.
• High-dose Zinc & Copper: Too much zinc can deplete copper, leading to fatigue. If you take zinc long-term, add a little copper.
• Blood Thinners (Warfarin, Aspirin, etc.): Quercetin, Vitamin K (in Whole Food Complex) and CoQ10 may affect blood clotting.  
• Blood Pressure Medications: Taurine, CoQ10 and NMN may lower blood pressure, potentially causing additive effects.  
• Diabetes Medications (Metformin, Insulin, etc.): NMN, TMG and Quercetin may influence blood sugar levels.  
• Chemotherapy or Immunosuppressants: Quercetin, Ergothioneine and Spermidine modulate immune function, which could interfere with treatment.  
• Stimulants (Caffeine, ADHD meds): Taurine may amplify or counteract stimulant effects.  

Sample Longevity Stack with Protocol X

Here’s how to properly stack supplements and how to stack Protocol X:

Morning:

• Protocol X: Mix one sachet of Protocol X™ with 200–250ml of water or your preferred drink and stir well. It’s best taken on empty stomach.
• Resveratrol: Take with food (especially healthy fats like avocado or nuts) to help absorption. 
• Omega-3s (Fish Oil): Take omega-3s at breakfast or lunch (fat-soluble, so take with food). Also better with food to avoid fishy burps. 

Midday:

• Fisetin: Only needed once a month (as a ‘senolytic reset’). Take with a fatty meal (like olive oil or full-fat yoghurt) for best results.
• Probiotics: Take with food to help the good bacteria survive stomach acid. Avoid hot drinks right after.

After Workout:

• Protein Powder: Helps muscles recover fast. Mix with water or milk. (If you don’t workout, take it with any meal.)
• Creatine: If you need extra.

Evening:

• Zinc: Take with dinner (can cause nausea on an empty stomach). Avoid calcium-rich foods (like cheese) at the same time — they block absorption.
• Magnesium: 30–60 mins before bed. Helps relaxation and deep sleep.
• Apigenin: Drink chamomile tea or take as a supplement right before bed. Works like a natural sleep aid.

Looking for a longevity supplements list? Read our article on the top 15 anti-ageing supplement worth buying.

End Note: Listen to Your Body

When building your anti-ageing supplement stack, remember that everyone is different, so start slow, track how you feel and adjust as needed. For best results, consider getting blood work to check nutrient levels before stacking.

Want to dive deeper? Check out these expert stacks:

• David Sinclair Supplements List
• Bryan Johnson Supplement Stack
• Valter Longo Supplement Stack
• Andrew Huberman Supplement Stack

By stacking Protocol X wisely, you can boost its benefits and support a longer, healthier life.

Ready to boost your anti-ageing goals? Start building your longevity supplement stack today!

What is the best supplement for longevity? Learn more about anti-ageing supplements and your health through our blogs!