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Helps activate autophagy, your cells’ built-in renewal system. Clinically studied to help support hair follicle health, cognitive function, and healthy aging.

Key benefits

✦ Activates autophagy, the body's natural cellular renewal process
✦ Clinically shown to increase active hair follicles by over 50% in 90 days
✦ Supports cognitive performance as part of healthy aging
✦ 10mg of pure spermidine, 99%+ verified purity. One a day.

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Description

Spermidine is a natural compound found in every cell of your body. It helps activate autophagy – the process your cells use to clear out damaged components and recycle them into raw materials for new, healthy cells. Your body produces less of it with age, and cell renewal, hair follicle health, and cognitive function quietly decline with it.

Most spermidine supplements deliver 1–5 mg per capsule from wheat-germ extract, often without third-party purity verification. Ours delivers 10 mg of pure spermidine at above 99% verified purity, manufactured in a GMP-certified facility and third-party lab tested.

If pregnant, nursing, or on medication, consult a physician before use.

[11.11 Special] 1x SPERMIDINE

THE DIFFERENCE YOU'LL NOTICE

Thicker, healthier-looking hair

More active hair follicles over time; most people notice by month three.

Steadier energy

Support for the cellular renewal process that keeps energy from flagging as you age.

Clearer thinking

Support for cognitive performance as part of healthy aging.

Thicker, healthier-looking hair

More active hair follicles over time; most people notice by month three.

Steadier energy

Support for the cellular renewal process that keeps energy from flagging as you age.

Clearer thinking

Support for cognitive performance as part of healthy aging.

GMP, HACCP, Gluten-free, Non-GMO, GRAS, Natural ingredients, No artificial colors, No artificial fragrance, Alcohol-free, Phosphate-free, and Vegan

XANDRO QUALITY ASSURANCE

Third-Party Tested

XANDRO products undergo third-party testing for every batch produced. In addition, we continuously test for stability through the year.

GMP-CERTIFIED, HACCP-CERTIFIED, THIRD-PARTY TESTED, DEVELOPED IN SINGAPORE, NON-GMO, DAIRY-FREE, GLUTEN-FREE, ADDITIVE-FREE, and VEGAN

THE SCIENCE

The Evidence So Far

Spermidine targets one process: as natural spermidine levels decline with age, so does autophagy, the cellular process that clears out damaged proteins, recycles worn-out components, and renews cells. Fasting also triggers this pathway, but spermidine offers a dietary route to the same mechanism.

That slowdown shows up across multiple systems. In a 90-day controlled trial, a spermidine-based supplement increased active-phase hair follicles by 51.9%, while the placebo group declined by approximately 20%. In a three-month pilot study, supplementation was associated with moderate memory improvements in older adults.

The data extends to cardiovascular and immune health: higher dietary spermidine intake has been associated with reduced heart failure risk, and spermidine has been associated with supporting T-cell function in aging human immune cells.

Why does cellular renewal slow down?

Autophagy

Spermidine Levels Decline With Age

Natural spermidine production drops over time, slowing the cellular renewal process it drives

20%

Fewer Active Hair Follicles

Placebo groups saw active hair follicles decline by approximately 20% over 90 days (Rinaldi et al., 2017)

Cognitive Function

Cognitive Decline Without Support

Higher dietary polyamine intake was associated with markers of cardiovascular health. (Han et al., 2024)

How SPERMIDINE Works

AUTOPHAGY ACTIVATION

Helps activate your body's cellular cleanup process. Damaged proteins and worn-out components are tagged, broken down, and recycled into raw materials for new, healthy cells.

HAIR FOLLICLE SUPPORT

Clinically shown to increase active hair follicles by over 50% in 90 days.

COGNITIVE SUPPORT

Found in high concentrations in brain tissue. A three-month pilot study linked spermidine supplementation to moderate memory improvements in older adults.

Xandro Spermidine vs Others

Xandro Spermidine vs Others

Recommended

[11.11 Special] 1x SPERMIDINE

Recommended

Other Spermidine Supplements

  • PURITY

  • DOSE PER CAPSULE

  • THIRD-PARTY TESTED

  • GMP-CERTIFIED FACILITY

PURITY

Above 99%, verified

DOSE PER CAPSULE

10mg

THIRD-PARTY TESTED

Yes, COA publicly available

GMP-CERTIFIED FACILITY

Yes

PURITY

Varies; not always third-party verified

DOSE PER CAPSULE

Often lower, 1–5mg

THIRD-PARTY TESTED

Often not disclosed

GMP-CERTIFIED FACILITY

Varies

GMP, HACCP, Gluten-free, Non-GMO, GRAS, Natural ingredients, No artificial colors, No artificial fragrance, Alcohol-free, Phosphate-free, and Vegan

EVIDENCE MATTERS

Explore the current available evidence from the XANDRO science desk

EXPLORE SCIENCE

GMP, HACCP, Gluten-free, Non-GMO, GRAS, Natural ingredients, No artificial colors, No artificial fragrance, Alcohol-free, Phosphate-free, and Vegan