Science
Science is the product
Every formula we sell starts with peer-reviewed evidence. We partner with leading institutions, test every batch, and track outcomes with biomarkers — not guesswork.
Mechanism-first formulation
We start with the biological pathway, not the ingredient trend.
Third-party tested, every batch
COA available on request. Purity and potency verified externally.
Institutional partnerships
Working with NUS and primary peer-reviewed sources.
Biomarker-tracked outcomes
We measure NAD+, run diagnostics, and iterate based on data.
Research built on evidence
National University of Singapore — Research Collaboration
Xandro Lab works with NUS researchers to validate formulations and explore the science of healthy aging in Asian populations. Our joint webinar on longevity nutrition is available to watch below.
Watch the NUS webinar →Duke-NUS 2014 — Nature Publication
The MFSD2A discovery by Nguyen et al., published in Nature in 2014, established that LPC-DHA — not free DHA — is the primary form in which omega-3 crosses the blood-brain barrier. This is the peer-reviewed basis for LPC NEURO.
Read the Nature paper →From mechanism to product
Identify the mechanism
We start with a biological pathway backed by peer-reviewed research — not an ingredient that's currently trending.
Source the clinical form
We use the exact bioavailable form shown to work in studies — not a cheaper analogue that skips the evidence.
Third-party lab test
Every batch is independently tested for purity and potency. Certificates of Analysis available on request.
Track with biomarkers
We run our own NAD+ and diagnostic testing protocols and continuously review outcomes to improve formulations.
Scientific team & advisors
Xandro Lab combines in-house product science with advisory expertise spanning NAD+ biochemistry, exercise physiology, lipid metabolism, and healthy longevity research.
Dr Eugene He
Founder & Chief Product Officer, Xandro Lab
Product strategy, ingredient sourcing, and clinical formulation direction.
Dr Toby Chin
Principal Scientist, Xandro Lab
Research review, evidence evaluation, and formulation scientific oversight.
Professor Nguyen Nam Long
Associate Professor, NUS Yong Loo Lin School of Medicine
Lipid transport, MFSD2A biology, blood-brain barrier, and DHA metabolism. Lead author, 2014 Nature paper.
Professor Vincenzo Sorrentino
Assistant Professor, Biochemistry & Healthy Longevity TRP, NUS
NAD+ metabolism, mitochondria, proteostasis, and aging. Publications in Nature and Cell Reports.
Professor Jorming Goh
Assistant Professor, Exercise Physiology, NUS
Exercise science, metabolic health, and physical performance in aging populations.
Kamil Pabis
Research Scientist
Longevity biology, ingredient evidence review, and mechanistic research.
Dr Hisham
Past Research Advisor
Science behind each product
LPC NEURO — Lysoveta® LPC-DHA
Your brain has a barrier. Most fish oil struggles to cross it. LPC NEURO uses Lysoveta® LPC-DHA — the only form of omega-3 that crosses the blood-brain barrier via the MFSD2A transporter, discovered by Duke-NUS in a 2014 Nature study.
The blood-brain barrier (BBB) is a tight cellular wall that blocks most large molecules from entering the brain. Standard fish oil contains free DHA, which cannot cross the BBB efficiently, as it is not a substrate for the MFSD2A transporter that guards this interface. In 2014, researchers at Duke-NUS discovered that MFSD2A specifically recognises and actively transports DHA only when bound to lysophosphatidylcholine (LPC). Lysoveta® replicates this form at pharmaceutical-grade purity — 500mg per serving.
Nguyen et al., 2014
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature, 509(7501):503–506. Duke-NUS Medical School. Discovered MFSD2A as the specific BBB transporter for LPC-DHA; mice lacking MFSD2A had severely reduced brain DHA and microcephaly.
Alakbarzade et al., 2015
A partially inactivating mutation in MFSD2A causes a non-lethal microcephaly syndrome. Nature Genetics, 47(7):814–817. First human genetic evidence that impaired LPC-DHA transport leads to progressive neurological decline.
Cunnane et al., 2012
Plasma and Brain Fatty Acid Profiles in Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's Disease, 29(3):691–697. Brain and plasma DHA levels are reduced in Alzheimer's disease and MCI vs. cognitively healthy individuals.
- Naturally occurring phospholipid form, well-tolerated in clinical use
- Consult physician if pregnant or on blood thinners
- Derived from fish — not suitable for vegans
Why can't I just take fish oil instead?
How long until I notice a difference?
Is it suitable for vegans?
Protocol X V3 — NMN + Calcium AKG + Quercetin
Three interdependent longevity pathways: NAD+ restoration via NMN, AKG-mediated epigenetic remodelling via Calcium AKG, and senescent cell clearance via Quercetin.
NAD+ is a coenzyme essential for energy production, DNA repair, and sirtuin activity. Levels fall by ~50% between ages 20 and 60. NMN is the immediate precursor to NAD+ in the NAMPT-dependent salvage pathway — bypassing the rate-limiting NAMPT step.
Yi et al., 2023
Efficacy and safety of β-NMN supplementation in healthy middle-aged adults. GeroScience, 45(1):29–43. 60-day RCT in 80 adults 40–65; NMN (300–900mg/day) increased blood NAD+ dose-dependently and improved walking distance.
Okabe et al., 2022
Oral administration of NMN is safe and efficiently increases blood NAD+ levels. Frontiers in Nutrition, 9:868640. 12-week RCT in 31 healthy adults; 250mg/day NMN significantly increased whole blood NAD+ with no adverse effects.
Dosing in Protocol X V3: 400mg per sachet, morning, 99.9% purity verified.
Alpha-ketoglutarate (AKG) is a key TCA cycle intermediate that declines nearly tenfold between ages 40 and 80. AKG is a co-factor for TET DNA demethylases, supporting a younger epigenetic profile, and inhibits mTOR while activating AMPK.
Demidenko et al., 2021
Rejuvant®, a life-extending compound with alpha-ketoglutarate, conferred an average 8-year reduction in biological aging. Aging (Albany NY), 13(22):24485.
Shahmirzadi et al., 2020
Alpha-Ketoglutarate Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metabolism, 32(3):447–456. Buck Institute. Extended median lifespan ~16.6% in mice, reduced frailty scores.
Dosing: 500mg per sachet, calcium salt form, daily.
Why calcium AKG and not plain AKG?
Quercetin is a senolytic flavonoid. As cells age, some become senescent — secreting pro-inflammatory signals that damage neighbouring cells. Quercetin selectively eliminates these cells by inhibiting the BCL-2 and BCL-XL proteins they rely on to survive.
Hickson et al., 2019
Senolytics decrease senescent cells in humans. EBioMedicine, 47. First human clinical evidence that senolytic treatment decreases senescent cell burden.
Dosing: 200mg per sachet, with food, daily.
Why is quercetin in Protocol X and not standalone?
NMN — β-Nicotinamide Mononucleotide
Direct NAD+ precursor for cellular energy, metabolic resilience, and healthy ageing.
NAD+ is essential for mitochondrial energy production, DNA repair via PARP enzymes, and longevity signalling via sirtuins. NMN is the immediate precursor to NAD+ in the NAMPT-dependent salvage pathway, bypassing the rate-limiting NAMPT step that becomes less efficient with age.
Yi et al., 2023
Efficacy and safety of β-NMN in healthy middle-aged adults. GeroScience, 45(1):29–43. 60-day RCT; increased blood NAD+ dose-dependently, improved walking distance and biological age markers.
Yoshino et al., 2021
NMN increases muscle insulin sensitivity in prediabetic women. Science, 372(6547):1224–1229. 10-week RCT; 250mg/day increased insulin-stimulated glucose disposal.
Morifuji et al., 2024
β-NMN maintained walking speed and improved sleep quality in older adults. GeroScience, 46(5):4671–4688. 12-week RCT in adults 65+.
Liao et al., 2021
NMN supplementation enhances aerobic capacity in amateur runners. J. Int. Society of Sports Nutrition, 18:1–9.
| NAM | NR | NMN | |
|---|---|---|---|
| Steps to NAD+ | 2 | 2 | 1 |
| Bypasses NAMPT | ✗ | ✗ | ✓ |
| Sirtuin inhibition risk | ✓ (high dose) | ✗ | ✗ |
| Physical function data | Limited | Limited | Yes |
- Well tolerated at 250–900mg/day across multiple RCTs, no serious adverse events
- Vegetarian hypromellose capsule — suitable for vegans
- Consult physician if pregnant, breastfeeding, or on medication
Why does NAD+ decline with age?
How long until I notice a difference?
Can I take it with food?
Magnesium Glycinate
Most people don't get enough magnesium. Even fewer absorb it well.
Magnesium is involved in over 300 enzymatic reactions. Magnesium glycinate pairs elemental magnesium with glycine, an amino acid that acts as a carrier, improving absorption and reducing digestive side effects associated with forms like magnesium oxide.
Abbasi et al., 2012
Magnesium supplementation on primary insomnia in elderly. J. Research in Medical Sciences, 17(12):1161–1169. Increased sleep time and efficiency, reduced insomnia severity.
Veronese et al., 2014
Oral magnesium on physical performance in healthy elderly women. Am. J. Clinical Nutrition, 100(3):974–981. Improved physical performance battery score and walking speed.
Reno et al., 2022
Magnesium supplementation on muscle soreness and performance. J. Strength and Conditioning Research, 36(8):2198–2203.
| Form | Absorption | Tolerability | Best for |
|---|---|---|---|
| Magnesium Oxide | Low | Poor at high doses | Low cost only |
| Magnesium Citrate | Moderate | Moderate | General use |
| Magnesium Glycinate | High | Excellent | Sleep, recovery, daily use |
| Magnesium Malate | Moderate | Good | Energy support |
When is the best time to take it?
Can I take it with other Xandro products?
Joint Recovery — Mangoselect® + SCP-II Proteoglycan
Real relief. No NSAIDs. No side effects.
A patented mangosteen extract standardised to two xanthones: α-mangostin and γ-mangostin. γ-Mangostin directly inhibits COX-1 and COX-2 — the same pathway targeted by NSAIDs, but through a natural compound.
Romain & Cases, 2015
Mangosteen extract for short-term pain management. Agro Food Industry Hi-Tech, 26(3):8–13. Reduced soft tissue pain by 37.4% in 5 days.
Extracted from salmon nasal cartilage, containing undenatured type II collagen and proteoglycans — the same molecules that make up human joint cartilage.
Tomonaga et al., 2017
Salmon nasal proteoglycan on cartilage metabolism biomarkers. Exp. and Therapeutic Medicine, 14(1):115–126. 16-week RCT; significantly reduced type II collagen degradation.
| Joint Recovery | Glucosamine & Chondroitin | NSAIDs | |
|---|---|---|---|
| Time to relief | As little as 5 days | 4–8 weeks | 1–2 hours |
| Supports cartilage | ✓ | ✓ | ✗ |
| Long-term safety | ✓ | ✓ | ✗ (GI/kidney/liver risk) |
How does Joint Recovery differ from glucosamine?
NEURO X — Six ingredients, six mechanisms
Each ingredient selected for what it does, not how it sounds: Somin-on™, BacoMind™, Neuroflow™ PS, Mitoprime™, Salidropure™, and Cognivia®.
Standardised to sominone (NLT 2%), a neuroactive ashwagandha metabolite that activates the RET receptor, triggering ERK/AKT signalling that promotes neuronal growth and synaptic density.
Rai & Mishra, 2025
Ashwagandha extract with Sominone improves memory in mild cognitive impairment. J. Psychopharmacology, 39(4):350–363. 60-day RCT improved memory, recall, and cognitive composite scores.
A standardised Bacopa monnieri extract. Bacosides inhibit acetylcholinesterase, keeping more acetylcholine available for memory consolidation.
Morgan & Stevens, 2010
Does Bacopa monnieri improve memory in older persons? J. Alternative and Complementary Medicine, 16(7):753–759.
Phosphatidylserine is the most abundant phospholipid in neuronal membranes. Supplementing PS restores membrane integrity and neurotransmitter release.
Duan et al., 2025
Phosphatidylserine on cognitive function in older adults with MCI. J. Affective Disorders, 369:35–42. 12-month RCT improved memory and reasoning.
L-Ergothioneine is actively concentrated in the brain and mitochondria via the OCTN1 transporter, neutralising oxidative stress where it matters most.
Yau et al., 2024
Ergothioneine to delay cognitive decline in MCI subjects. J. Alzheimer's Disease, 102(3):841–854.
Precision-fermented salidroside, the principal bioactive of Rhodiola rosea, moderating HPA axis activity and preserving dopamine availability.
Darbinyan et al., 2000
Rhodiola rosea in stress induced fatigue. Phytomedicine, 7(5):365–371.
A dual-extract sage formulation inhibiting acetylcholinesterase, preserving acetylcholine for attention and working memory.
Wightman et al., 2021
Acute and chronic cognitive effects of a sage extract. Nutrients, 13(1):218.
How is Somin-on™ different from regular ashwagandha?
Ingredient index
| Ingredient | Used in |
|---|---|
| NMN | Protocol X V3, NMN |
| Calcium AKG | Protocol X V3 |
| LPC-DHA (Lysoveta®) | LPC NEURO |
| Quercetin | Protocol X V3 |
| Magnesium Glycinate | Magnesium Glycinate |
| Mangoselect® | Joint Recovery |
| SCP-II Proteoglycan | Joint Recovery |
| BacoMind™ | NEURO X |
Watch our research webinar
Our collaboration with NUS brought together researchers and practitioners to discuss the science of longevity nutrition, including the mechanisms behind our formulations.
