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How Protocol X® V3 Boosts Your Longevity

Have you ever thought about what's the best supplement for anti-aging? Well, XANDRO's here to help.

Protocol X® V3 is our latest, science-upgraded longevity supplement – built as an all-in-one daily sachet that supports healthy aging, energy, recovery, and resilience. As verified longevity science evolves, so does Protocol X.

Maintaining our promise to keep evolving Protocol X with validated longevity science developments, Protocol X V3 keeps the original healthy longevity essentials, increases key doses, removes redundancies, and adds new ingredients where the evidence is exciting.

This is a longevity blend full of scientifically backed ingredients. We'll go over each ingredient and what its role is in the blend.

Further Reading: Longevity Pathways

WHAT CHANGED IN PROTOCOL X® V3 (UPDATED 2025)

We didn't reformulate for the sake of it. We updated Protocol X as the science – and the standards – evolved:

• NMN up to 400mg (up from 250mg)
• Creatine doubled to 2000mg (up from 1000mg)
• Added: Glycine (500mg) + Cordyceps (400mg) for recovery, resilience, and performance aging
• Removed: Citrusvel® Citrus Bioflavonoids Complex to keep the blend tighter and more evidence-aligned

Now let's get into the good stuff: here's what's inside Protocol X V3 – and the science behind why each ingredient earned its place.

Key Ingredients in Protocol X® V3

• Glycine (New in V3)
• Cordyceps (New in V3)
• NMN
• Creatine Monohydrate
• Quercetin
• Sialic Acid (N-acetylneuraminic acid)
• Phosphatidylcholine
• Vegan Collagen Booster VC-H1®
• CaAKG
• Taurine
• Ergothioneine
• Vitamin C
• Vitamin D3
• CoQ10 (Ubiquinol)
• TMG
• Spermidine
• L-Glutamine
• Whole Food Complex
• Sodium Hyaluronate

This longevity supplement contains a range of anti-aging ingredients – but don't just take our word for it. Let's dive into the scientific research (and practical "why it matters") supporting each ingredient.

New in V3: Glycine 500mg 

Glycine is a simple amino acid with surprisingly strong relevance to recovery and longevity-focused routines – one reason it was added to V3.

• Sleep quality support: Studied for supporting sleep onset and restorative sleep.
• Recovery + repair support: Involved in tissue repair and collagen pathways, complementing VC-H1® in V3.
• Cellular clean-up support: Studied in relation to autophagy and healthy aging mechanisms.

New in V3: Cordyceps (Cordyceps sinensis stroma extract, cultivated) 400mg 

Cordyceps is a functional mushroom used traditionally and now studied as an adaptogen-like ingredient, which is why it's part of V3.

• Endurance support: Studied for oxygen utilisation and performance markers (VO₂-related outcomes).
• Energy support: Investigated for ATP and mitochondrial-related support.
• Immune resilience support: Studied for immune-modulating potential and stress adaptation.

Doubled in V3: NMN (β-Nicotinamide Mononucleotide) – 400mg

NMN is a precursor to NAD+, a molecule central to cellular energy, DNA repair pathways, and mitochondrial function. In Protocol X V3, NMN is increased to 400mg for stronger cellular energy support.

• Cellular energy support: Supports NAD+ pathways linked to energy and mitochondrial function.
• Metabolic support: Studied for roles in metabolic health markers.
• Cognitive support: Studied in relation to brain energy and cognitive aging.
• Healthy aging support: A flagship longevity ingredient with growing human research.

Further Reading: How NMN May Help With Menopause

Doubled in V3: Creatine Monohydrate – 2000mg

Creatine is one of the most studied supplements in the world – and it's not just for gym-goers. In Protocol X V3, creatine is doubled to 2000mg to support high-performance aging:

• Muscle + strength support: Supports performance, strength, and recovery, especially as we age.
• Brain + cognitive support: Studied for brain energy support and cognitive performance in certain groups.
• Cellular energy support: Helps recycle ATP (cell energy), relevant to both body and brain.

Quercetin 200mg

Quercetin is a plant compound (polyphenol) with antioxidant properties. It's commonly found in fruits and vegetables and has been part of human diets for centuries, although the human body cannot make it.

For those interested in longevity, quercetin may support:

• Antioxidant support: Helps neutralize oxidative stress.
• Inflammation balance: Supports a healthier inflammatory response.
• Cardiovascular support: May support healthy blood vessel function.
• Metabolic support: May support healthy glucose and lipid metabolism.
• Neuro-support: Studied for its potential role in brain health and healthy aging.

Sialic Acid (N-acetylneuraminic acid) 25mg

Sialic acid is a naturally occurring molecule involved in cell signaling and "cell surface" functions. Here's why we've added it to Protocol X V3:

• Cognitive + brain support: Studied for potential roles in learning, memory, and brain function.
• Immune defense support: Helps support protective barrier functions on cell surfaces.
• Cardiometabolic support: Studied in relation to blood lipids and metabolic markers.
• Whole-body resilience: A "systems" ingredient that shows up in multiple longevity-adjacent pathways.

Phosphatidylcholine 100mg

Phosphatidylcholine (PC) is a phospholipid that helps support cell membranes. Here's why it's in Protocol X V3:

• Cellular health: Supports healthy cell membrane structure and function.
• Brain support: Supports acetylcholine pathways, which play a role in cognition and memory.
• Mitochondrial support: Phospholipids are structural components of mitochondria (your cellular energy factories).
• Liver + digestion support: Involved in bile-related pathways that support fat digestion.
• Gut barrier support: Studied for its role in intestinal lining support.

Vegan Collagen Booster VC-H1® (from Hibiscus sabdariffa flower extract)  1000mg

Protocol X V3 includes VC-H1®, a vegan collagen booster designed to support collagen pathways – which matter for skin, connective tissue, and recovery as we age.

Why we kept it (and refined it) in V3:

• Skin + elasticity support: Collagen pathways help support firmness and skin structure.
• Connective tissue support: Collagen is foundational for tendons, ligaments, and joint support.
• Recovery + repair support: Collagen turnover is part of how your body maintains tissue resilience over time.

Note: In V3, VC-H1® is streamlined to 1000mg as part of a tighter, synergy-first formulation – and we've also added glycine separately (see above), a key amino acid studied for sleep and repair.

Further Reading: Common Ingredients in Beauty Supplements

Ca-AKG 500mg

Calcium Alpha-Ketoglutarate (Ca-AKG) is a longevity-favorite ingredient that plays roles in cellular energy and metabolism. Here's why it's included:

• Cellular energy support: AKG is involved in core energy pathways.
• Amino acid metabolism: Supports amino acid-related pathways (including glutamine-related metabolism).
• Inflammation + resilience support: Studied for potential roles in healthier aging markers.
• Muscle + recovery support: Often discussed in the context of muscle preservation and performance aging.

Further Reading: The Benefits of Calcium AKG for Athletes

Taurine 1000mg

Taurine is an amino acid-like compound that's gained serious attention in healthy aging research. Here's why you might consider it in a longevity blend:

• Healthy aging support: Studied in aging models for multi-system benefits.
• Metabolic support: Studied for roles in glucose metabolism and insulin sensitivity.
• Cardiovascular support: Supports heart and vascular function pathways.
• Cellular resilience: Studied for mitochondrial support and stress response.

Ergothioneine 3mg

Ergothioneine (ERGO) is a dietary antioxidant found in mushrooms and often discussed as a "longevity antioxidant." Here's why it's in Protocol X V3:

• Antioxidant support: Helps neutralize oxidative stress, and is known for its stability compared to other antioxidants.
• Inflammation balance: Studied for anti-inflammatory potential.
• Healthy aging support: Investigated for roles in brain, eye, and cellular health over time.

Vitamin C (as L-ascorbic acid) 400mg

Vitamin C is an essential antioxidant with wide-ranging roles relevant to healthy aging:

• Antioxidant support: Helps protect cells from oxidative stress.
• Immune support: Supports immune function and healthy inflammatory balance.
• Collagen support: Vitamin C is essential for collagen synthesis pathways (skin + tissue support).
• Skin support: Helps support hydration, texture, and overall skin quality.

Further Reading: Does Chewing Vitamin C Reduce Its Effect?

Vitamin D3 (as cholecalciferol, sourced from lichen) 11mcg (1000 IU)

Vitamin D is crucial for overall health and longevity. In Protocol X V3, Vitamin D3 is dosed at 1000 IU and is now sourced from lichen, making it fully vegan.

• Bone + muscle support: Supports calcium absorption and bone health.
• Immune support: Supports immune function and resilience.
• Mood + brain support: Low vitamin D status is commonly linked to mood and cognitive outcomes in research.

CoQ10 (Ubiquinol) 30mg

Coenzyme Q10 supports cellular energy production and antioxidant defense. Ubiquinol is the reduced, more readily used form.

• Energy + vitality support: Supports mitochondrial energy production.
• Heart support: Studied for cardiovascular and metabolic health support.
• Antioxidant support: Helps neutralize oxidative stress, particularly in energy-demanding tissues.

Further Reading: The Power of CoQ10 Supplements

TMG (Betaine Anhydrous) 200mg

TMG is a methyl donor that supports methylation pathways – which are relevant to healthy aging and cellular function.

• Methylation support: Supports methylation pathways involved in gene expression and cellular maintenance.
• Homocysteine support: Helps support healthy homocysteine metabolism.
• Performance support: Studied for potential benefits in training output and body composition.

Spermidine 3HCL 1mg

Spermidine is often discussed for its relationship with autophagy – your body's cellular "clean-up and recycle" system. That's one reason it's popular in longevity stacks.

• Autophagy support: Studied as a compound associated with cellular renewal pathways.
• Healthy aging support: A longevity-adjacent ingredient with emerging human research.

Further Reading: Answering Spermidine FAQs

L-Glutamine 800mg

Glutamine is an amino acid your body uses heavily during stress, intense training, and immune challenges.

• Gut lining support: Commonly studied for gut barrier and digestive support, especially under stress.
• Immune support: Fuels immune cells and supports resilience during heavy training or fatigue.
• Recovery support: Plays roles in muscle recovery and whole-body repair.

Whole Food Complex 1000mg

Protocol X V3 includes a whole food complex made from a range of fruit and plant powders – a "nutrient diversity" layer that supports overall antioxidant intake and polyphenol variety.

• Antioxidant + polyphenol support: Helps support oxidative balance.
• Dietary "coverage" support: A practical way to add a spectrum of phytonutrients to your daily routine.
• Recovery support: Antioxidant-rich foods are often discussed in the context of exercise recovery and resilience.

Sodium Hyaluronate 50mg

Sodium hyaluronate is a form of hyaluronic acid often used for hydration and joint support.

• Skin hydration support: Supports skin moisture and suppleness. Hyaluronic acid levels decline significantly with age, so consistent intake matters.
• Joint comfort support: Supports joint lubrication and movement comfort.
• Tissue support: A structural-support ingredient relevant to connective tissue health.

Who Should Take Protocol X V3?

Protocol X V3 is designed for people who want a practical, all-in-one longevity blend – especially if you care about energy, recovery, cognitive clarity, resilience, and performance as you age.

It may be a fit for:

• Active agers (40s–60s+): People focused on vitality, metabolism, cognition, and recovery as the years stack up.
• Athletes + busy high-performers: People who train hard (or just live hard) and want daily support for recovery and resilience.
• Longevity lifestyle users: People building consistent, long-term routines around healthspan support.

Read more about who Protocol X will benefit here!

End Note

Protocol X® V3 is intended to supplement your healthy diet, exercise, sleep, and stress management habits – supporting your healthspan from within.

Speak with your doctor before adding any supplement to your longevity stack, especially if you have a medical condition, are pregnant or breastfeeding, or are taking medications.

Are you looking for more of the best longevity supplements? Try out the other supplements from our health nutrition store, including vitamin D3+K2, Calcium AKG, Pure NMN and Spermidine supplements. These are included in Protocol X® V3, but you may find taking individual ingredients suits your longevity targets more – it's totally up to you!