dr. he Metabolyn™ 3 - Advanced Blood Sugar & Homocysteine Support

dr. he Metabolyn™ 3 is an advanced supplement designed to help manage key markers of metabolic health — including blood pressure, cholesterol, and blood sugar. Developed by renowned expert Dr. Eugene He, this proprietary blend combines scientifically validated ingredients with the wisdom of natural medicine to support overall heart and metabolic wellness.

Who is Dr. He Metabolyn™ 3 for?

dr. he Metabolyn™ 3 is suitable for:

• Adults seeking natural support for cardiovascular health, healthy cholesterol or blood pressure levels
• Those managing glucose balance or insulin sensitivity
• Health-conscious individuals focused on preventive wellness and who want to maintain an active lifestyle
• People preferring stimulant-free, food-based supplements

The Science Behind dr. he Metabolyn™ 3?

dr. he Metabolyn™ 3’s scientifically studied mechanisms of action include:

Glucose & Metabolism

• Mango extract (Care300®) is shown to support insulin sensitivity and energy metabolism.¹ ² ³
• Activates AMPK and SIRT1 – enzymes associated with energy regulation and metabolic resilience.¹ ²

Heart Health & Circulation

• ABG10+ aged black garlic supports vascular relaxation and circulation.⁴ ⁵ ⁶
• Nattokinase supports healthy blood flow and helps maintain normal blood pressure.⁷ ⁸ ⁹

Cholestrol & Lipid Balance

• ABG10+ can support a favorable cholesterol profile. ABG10+ supplementation reduced LDL by 22%, triglycerides by 24%, and increased HDL by 46% in hypercholesterolemic individuals.¹⁰ ¹¹
• Amla extract supports healthy lipid levels including LDL, HDL and triglycerides.¹²

Homocysteine Support

• Essential B-vitamins (B6, folate, B12) help maintain optimal homocysteine levels.¹³ ¹⁴ ¹⁵
• Supplementation can reduce homocysteine levels by up to 25% and support cardiovascular and neurological health.¹³ ¹⁵

What Makes dr. he Metabolyn™ 3 Different?

How To Take dr. he Metabolyn™ 3 

Dosage: Take 2 vegetarian capsules daily, with or without food.

Consistency is key: Daily use is recommended for best results.

Safe for long-term use under typical conditions. No stimulants, artificial preservatives or fillers.

References: 

1. Buchwald-Werner et al. Effects of Mangifera indica (Careless) on Microcirculation and Glucose Metabolism in Healthy Volunteers. Planta Med 2017. DOI 10.1055/s-0043-1103017. 
2. Röchter et al. Benefits of a Mangifera indica L. fruit powder for well-aging: In vitro investigation of effects on master regulators for the aging process. Agro FOOD Industry Hi Tech 2015; 26(3). 
3. Gerstgrasser et al. In Vitro Activation of eNOS by Mangifera indica (Careless™) and Determination of an Effective Dosage in a Randomized, Double-Blind, Human Pilot Study on Microcirculation. Planta Med 2016. DOI: 10.1055/s-0035-1558219
4. Sabater et al. Consumption of a Mango Fruit Powder Protects Mice from High-Fat Induced Insulin Resistance and Hepatic Fat Accumulation. Cell Physiol Biochem 2017; 42: 564-578. DOI: 10.1159/000477606
5. García-Villalón AL et al. In vitro studies of an aged black garlic extract enriched in S-allylcysteine and polyphenols with cardioprotective effects. J Funct Foods 2016; 27: 189-200. https://doi.org/10.1016/j.jff.2016.08.062
6. Ried K et al. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas 2010; 67: 144-150. DOI: 10.1016/j.maturitas.2010.06.001
7. Kim, J., Gum, S., Paik, J. et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res 31, 1583–1588 (2008). DOI: 10.1291/hypres.31.1583
8. Hsia, C-H., Shen, M-C., Lin, J-S., Wen, Y-K., Hwang, K-L., Cham, T-M., Yang, N-C. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutrition Research 29(3), 190-196 (2009). https://doi.org/10.1016/j.nutres.2009.01.009 
9. Lampe, B.J., English, J.C. Toxicological assessment of nattokinase derived from Bacillus subtilis var. natto. Food and Chemical Toxicology 88, 87-99 (2016). https://doi.org/10.1016/j.fct.2015.12.025 
10. Amor S et al. Nutrients 2019; 11: 153. DOI: 10.3390/nu11010153
11. Rosa M, Valls et al. Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustained and Controlled Study. Nutrients 2022; 14: 405. https://doi.org/10.3390/nu14030405 
12. Upadya H, Prabhu S, Prasad A, et al. A randomized, double blind, placebo controlled, multicenter clinical trial to assess the efficacy and safety of Emblica officinalis extract in patients with dyslipidemia. BMC Complement Altern Med. 2019;19:27. https://doi.org/10.1186/s12906-019-2430-y  
13. Yuan S, Mason AM, Carter P, et al. Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study. BMC Med. 2021;19:97. https://doi.org/10.1186/s12916-021-01977-8  
14. Mandaviya PR, Stolk L, Heil SG. Homocysteine and DNA methylation: a review of animal and human literature. Mol Genet Metab. 2014;113(4):243-252. https://doi.org/10.1016/j.ymgme.2014.10.006
15. Mech AW, Farah A. Correlation of clinical response with homocysteine reduction during therapy with reduced B vitamins in patients with MDD who are positive for MTHFR C677T or A1298C polymorphism: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2016;77(5):668-671. https://doi.org/10.4088/JCP.15m10166 

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