Discover dr. he Metabolyn™ PRO, The Next-Gen Probiotic

Formulated with probiotic AKK plus 5 unique, multi-patented ‘crown’ strains, (CLA) and prebiotics. This advanced formula is powered by metabolic research to support a balanced gut microbiome and healthy metabolic function, digestion, mood and overall wellbeing. Delivers real, research-backed results.

• Supports healthy weight management, gut health, metabolism, and mood.
• Features crown strains: scientifically selected probiotics with superior stability and targeted benefits.
• Developed with Dr. Eugene He, renowned expert in nutraceutical research and naturopathic medicine.
• In collaboration with Bioflag (Asia’s leading probiotic research group).

Who is dr. he Metabolyn™ PRO for?

dr. he Metabolyn™ PRO is formulated for adults looking to support their gut health, metabolism, and overall well-being. It’s ideal for:

• Individuals seeking weight management support through improved metabolism and gut balance.
• People experiencing digestive discomfort like bloating or sluggish digestion.
• Those looking for enhanced mood, better sleep, and stress reduction as part of their wellness routine.
• Adults with busy lifestyles who want a probiotic formula backed by science to improve energy and support long-term health.

Anyone looking to optimize their gut microbiome and boost immunity naturally.

The Science Behind dr. he Metabolyn™ PRO

Backed Clinical Studies

1. Weight Management & Fat Reduction

• B-3 probiotic reduced body fat by 0.6 kg and fat % by 0.7% after 12 weeks¹ ² ³.
• AKK supplementation resulted in significant reductions in body fat and weight after 12 weeks in individuals with type 2 diabetes⁴.

2. Digestive Comfort

• BL-99  significantly improved functional dyspepsia (indigestion) symptoms to 90% vs 58% in placebo⁵.

3. Immunity & Microbiome Balance

• CP-9 accelerated bilirubin clearance in infants, demonstrating systemic gut benefits⁶.
  

4. Mood & Mental Health

• K56 led to a significant reduction in anxiety and improved sleep scores⁷ ⁸.
  
  
• CCFM1025 improved depression scores in MDD patients in 4 weeks⁹ ¹⁰.
  

What Makes dr. he Metabolyn™ PRO Different?

A new class of probiotics – powered by crown strains and metabolic research.

Directions of Use

• Take 1 sachet daily, directly into the mouth or mix with cool water. Best taken after meals. 
• Safe for adults 16+.
• Suitable for long-term use.

References: 

1. Minami J, Iwabuchi N, Tanaka M, et al. Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: a randomized, double-blind, placebo-controlled trial. Biosci Microbiota Food Health. 2018;37(3):67-75. doi:10.12938/bmfh.18-001
2. Sung HK, Youn SJ, Choi Y, Eun SW, Shin SM. Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial. Nutrients. 2022;15(1):28. doi:10.3390/nu15010028
3. Minami J, Kondo S, Yanagisawa N, et al. Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial. J Nutr Sci. 2015;4:e17. doi:10.1017/jns.2015.5
4. Zhang Y, Liu R, Chen Y, et al. Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut. Cell Metab. 2025. Advance online publication. doi:10.1016/j.cmet.2024.12.010
5. Zhang Q, Li G, Zhao W, et al. Efficacy of Bifidobacterium animalis subsp. lactis BL-99 in the treatment of functional dyspepsia: a randomized placebo-controlled clinical trial. Nat Commun. 2024;15:227. doi:10.1038/s41467-023-44292-x
6. Tsai ML, Lin WY, Chen YT, et al. Adjuvant probiotic Bifidobacterium animalis subsp. lactis CP-9 improves phototherapeutic treatment outcomes in neonatal jaundice. Medicine. 2022;101(45):e31030. doi:10.1097/MD.0000000000031030
7. He J, et al. Effects of Lacticaseibacillus paracasei K56 on perceived stress among pregraduate students: a double-blind, randomized, placebo-controlled trial. Front Nutr. 2025. doi:10.3389/fnut.2025.1544713
8. Kadeer G, Fu W, He Y, et al. Effect of different doses of Lacticaseibacillus paracasei K56 on body fat and metabolic parameters in adult individuals with obesity: a pilot study. Nutr Metab (Lond). 2023;20:16. doi:10.1186/s12986-023-00739-y
9. Tian P, Chen Y, Zhu H, et al. Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial. Brain Behav Immun. 2022;100:233-241. doi:10.1016/j.bbi.2021.11.023
10. Lan Y, Lu J, Qiao G, et al. Bifidobacterium breve CCFM1025 Improves Sleep Quality via Regulating the Activity of the HPA Axis: A Randomized Clinical Trial. Nutrients. 2023;15(21):4700. doi:10.3390/nu15214700